de la hipertensión y la inhibición de los mecanismos de contrarregulación, así como en una reducción de los efectos adversos. calcioantagonistas. eficacia. Adicionalmente, el artículo se referirá a los potenciales efectos adversos del . lo mismo puede establecerse para los calcio antagonistas no dihidropiridínicos. También son muy bien tolerados con muy pocos efectos adversos, en su mayoría nadolol), antidepresivostricíclicos (amitriptilina)21, calcioantagonistas.

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Interacciones medicamentosas de agentes hipolipemiantes: Hypolipidemic agents drug interactions: Franco 1,4Y.

Henao 1M. Monsalve 1,4F. Se obtuvieron publicaciones, de las cuales se seleccionaron referencias, en las los que se identificaron interacciones.

To carry out a structures review of drug interactions of hypolipidemic drugs calciontagonistas to assess their clinical relevance. The following Mesh terms were used: The information was completed with those articles considered to be relevant.

Finally, a method was used to assess the clinical relevance of the interaction, based on the likelihood of occurrence and the severity of the effect of the interaction. Thirty-three of them were considered of very high risk level 1 and 42 of high risk level 2basically associated to increased risk for rhabdomyolisis.

Enzymatic inhibition of CYP was the most common mechanism for these interactions. Of the interactions identified in ca,cioantagonistas on hypolipidemic drugs, Most of these interactions are attributed to simultaneous use of CYP3A4 inhibitors.

Therefore, statins metabolized through CYP3A4 simvastatin, lovastatin and atorvastatin are the ones with the highest number of clinically relevant interactions. Drug interactions; Rhabdomyolisis; Hypolipidemic drugs. Similarmente, este efecto se presenta con la colestiramina y la glipizida El diltiazem puede causar un aumento en la Cmax en 3,6 veces y el ABC en 5 veces de la simvastatina y de 3,5 veces el ABC de lovastatina; efecto que no se evidencia en el caso de la pravastatina Estos efectos se deben posiblemente al efecto inhibidor de estos calcioantagonistas sobre la CYP3A4 De igual manera, la ciclosporina aumenta en 3,4 veces el ABC de ezetimiba Adicionalmente, el fenofibrato no presenta interacciones relevantes con colestipol o colesevelam El ezetimiba es bien tolerado y no interacciona con fluvastatinalovastatinarosuvastatina o simvastatina calcioantagonistaas Efecto que no ecectos observa para la pravastatina Interacciones medicamentosas de mayor relevancia en hipolipemiantes.

Por ello, las estatinas metabolizadas por la CYP3A4 como la simvastatina, lovastatina y atorvastatina son las estatinas que presentan mayor evidencia sobre las interacciones, mientras que la pravastatina posee un mejor perfil de seguridad debido a que no es metabolizado por CYP Pleiotropic effects of statins.

Risk for myopathy with statin therapy in high-risk patients. Baycol withdrawn from market. Interactions between statins and macrolide antibiotics. Interacciones medicamentosas en efecros infectados con el VIH: Fibrates in the treatment of dyslipidemias-time for a reassessment.

N Engl J Med. Severe rhabdomyolysis and acute renal failure secondary to concomitant use of simvastatin, amiodarone, and atazanavir. J Am Board Fam Med. FDA adverse event reports on statin-associated rhabdomyolysis. Ros E, Laguna JC. Tratamiento de la hipertrigliceridemia: Pharmacokinetic interactions between statins and fibrates.

Am J Cardiol ;96 suppl 9A: Use and indications of cholestyramine and bile acid sequestrants. Erythromycin and verapamil considerably increase serum simvastatin and simvastatin acid concentrations. Erythromycin coadministration increases plasma atorvastatin concentrations. Rhabdomyolysis secondary to a drug interaction between simvastatin and clarithromycin. Rhabdomyolysis associated with concomitant use of simvastatin and clarithromycin. Rhabdomyolysis caused by comedication with simvastatin and clarithromycin.

Rhabdomyolysis resulting from interaction of simvastatin and clarithromycin demonstrated by Tcm MDP scintigraphy. Lovastatin-induced rhabdomyolysis possibly associated with clarithromycin and azithromycin. A study of the interaction potential of azithromycin and clarithromycin with atorvastatin in healthy volunteers. Molden E, Andersson KS.

Simvastatin-associated rhabdomyolysis after coadministration of macrolide antibiotics in two patients. Multiple organ toxicity from addition of erythromycin to long-term lovastatin therapy. Drug qdversos caused by communication problems. Rhabdomyolysis due to a combination of itraconazole and simvastatin. Rhabdomyolysis after concomitant use of cyclosporine, simvastatin, gemfibrozil, and itraconazole. Rhabdomyolysis induced by simvastatin-fluconazole combination.

J Natl Med Assoc. A lesson for everyone in drug-drug interactions. Rhabdomyolysis from cytochrome p interaction of ketoconazole and simvastatin in prostate cancer. Rhabdomyolysis in a patient receiving atorvastatin calcioantagonista fluconazole.

Eur J Clin Pharmacol. Effect of itraconazole on the pharmacokinetics of atorvastatin. Itraconazole drastically increases plasma concentrations of lovastatin and lovastatin acid. Hepatitis and rhabdomyolysis in a patient with hormone refractory prostate cancer on ketoconazole and concurrent lovastatina therapy.

Effect of fluconazole on plasma fluvastatin and pravastatin concentrations. Different effects calcioantagonisats itraconazole on the pharmacokinetics of fluvastatin and lovastatin.

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Br J Clin Pharmacol. Simvastatin but not pravastatin is very susceptible to interaction with the CYP3A4 inhibitor itraconazole. The effect of fluconazole on the pharmacokinetics of rosuvastatin. Negredo E, Rey-Joly yC. Cardiovascular risk and human immunodeficiency virus infection: A new clinical challenge. Drug-drug interactions between raltegravir and pravastatin in healthy volunteers.

J Acquir Immune Defic Syndr. Pharmacokinetic interaction between nelfinavir and pravastatin ffectos HIV-seronegative volunteers: Pharmacokinetic interactions between protease inhibitors and statins in HIV efectoss volunteers: Simvastatin-nelfinavir interaction implicated in rhabdomyolysis and death. Rhabdomyolysis due to probable interaction between simvastatin and ritonavir.

Am J Health Syst Pharm. Pharmacokinetic interactions between calcioantagonistaw and 3-hydroxymethylglutaryl coenzyme A reductase inhibitors atorvastatin and simvastatin. Simvastatin coprescribed with protease inhibitors despite dangerous drug interactions. Effect of efavirenz on the pharmacokinetics of simvastatin, atorvastatin, and pravastatin: Interacciones medicamentosas de etravirina.

Enferm Infecc Microbiol Clin.

Endocrinol Metab Clin North Am. Gemfibrozil concentrations are significantly decreased in the presence of lopinavirritonavir.

Calcio-antagonistas by Leslie Melissa Jiménez Buendía on Prezi

Comunicado de la FDA sobre la seguridad de los medicamentos: Oates E, Dzintars K. Interaction between enfuvirtide, an injectable fusion inhibitor, and niacin in an HIV-infected patient.

Atorvastatin reduces the ability of clopidogrel to inhibit platelet aggregation: Not all statins interfere with clopidogrel during antiplatelet therapy.

Eur J Clin Invest. Lack of clopidogrel-statin interaction in patients undergoing coronary stent implantation. A randomised determination of the Effect of Fluvastatin and Atorvastatin on top of dual antiplatelet treatment on platelet aggregation after implantation of coronary drug-eluting stents.

Calcio Antagonistas by David Dominguez Guzman on Prezi

Influence of statin treatment on platelet inhibition by clopidogrel-a randomized comparison of rosuvastatin, atorvastatin and simvastatin co-treatment. Effect of atorvastatin on the pharmacokinetics and pharmacodynamics of prasugrel and clopidogrel in healthy subjects. Effects of rosuvastatin on platelet inhibition by clopidogrel in cardiovascular patients.

Platelet aggregation inhibition in patients receiving statins either fully or partially metabolized by CYP3A4. Proc West Pharmacol Soc. Effect of clopidogrel on calxioantagonistas steady-state pharmacokinetics of fluvastatin.


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The Third Carlist War Spanish: It is very often referred to as the “Second Carlist War”, as the ‘second’ — had been small in scale and almost trivial in political consequence. During this conflict, Carlist forces managed to occupy several towns in the interior of Spainthe most important ones being La Seu d’Urgell and Estella in Navarre.

Isabella II had abdicated the throne, and Amadeo Ia younger son of the King of Italy who had been proclaimed King of Spain inwas not very popular. The Carlist pretender, ” Carlos VII juah, grandson of ” Carlos V ” tried to earn the support of those areas with more region-specific customs and former laws.

The Carlists proclaimed the restoration of CatalanValencian and Aragonese fueros chartersabolished at the beginning of the 18th century by Philip V with the New Planning unilateral Royal decrees. After four years of war, on 28 Februarythe Carlist pretender went into exile in France.

The war caused between 7, and 50, casualties. carkos

The selection of Amadeo I was a great insult for the Carlists who at the time had strong support in northern Spain, especially in CataloniaNavarre and the Basque Provinces Basque Country. After some internal dissensions in —, ending with the removal of Cabrera as head of the Carlist partythe Carlists started a general uprising against Amadeo I ‘s government and its Liberal supporters.

The Third Carlist War became the final act of a long fight between Spanish progressives centralists and traditionalists which started after the Spanish Peninsular War from to and the promulgation of the constitution of Cadiz which ended the ancien regime in Spain. Mistrust and rivalry among members of the royal family also enlarged the conflict. The bell rings to the death across the heroic town of Igualada People death by bayonets, burned houses, factories attacked at dawn, robberies, rapings, insults About the Carlists’ entrance on Vendrell thousands atrocities are told, done by the followers of absolutism If our brothers fell to the edge of the Carlist dagger, why we the liberals have to be considered with them?

It is necessary to fight the war with war and to employ all kind of resources to exterminate the bandits that burn, steal and kill in the name of a religion and a peace. Carlism is named after the infant Carlos Maria Isidro —count of Molina and Fernando ‘s brother. The pragmatic sanctionpublished inabolished the ” Salic Law ” and so allowed women to be queens of Spain in their own right.

This meant that IsabelFernando ‘s daughter became the heir instead of Carlosthe king’s brother. Carlos almost instantly became the leader of Spain ‘s more conservative sections, and a cause around which to unite. Another important aspect of the Carlist ideology was its defense of the Catholic Church and its institutions, including the inquisition and the special tributary laws, against the comparatively more liberal crown.

The Carlists identified themselves with Spanish military traditions, adopting the Burgundian cross of the tercios in the 16th and 17th centuries. This nostalgia for Spain ‘s past was an important rallying point for Carlism. There was also a perceived support for the feudal system displaced by the French occupation, although this is disputed by historians.

The Carlists summarized this in a motto:. In the deeply religious and conservative atmosphere of 19th century Spain Carlism attracted a large number of followers, particularly among sections of society that perceived that they had lost influence due to the growing liberalism of the Spanish state.

Carlism found most of its supporters in rural areas particularly places which had previously enjoyed special status beforei. Catalonia and especially the Basque Country. In these parts of the country the Catholic peasantry and minor nobles were the bulwark of Carlist support, with occasional support from the major nobility, but other criteria of a national nature came also into play in these areas. As Fernando died in without a male heir the succession was disputed, despite the abrogation of the Salic law in As the new queen Isabel was only a child her mother, Maria Cristinabecame regent until Isabel was ready to reign in her own right.

As conservatives were backing CarlosMaria Cristina was forced to side with the Liberals, who sympathised with the ideals of the French revolution. Liberals were well represented in the higher reaches of the army and among the larger landowners, and also drew support among the middle classes.

The Liberals promoted Industrialization and Social modernization. Reforms included the sale of church lands and other institutions that supported the old regime, the establishment of electored parliaments, the construction of railways and the general expansion of industry throughout Spain.

There was a strong current of anti-clericalism. After Ferdinand’s death, the government went on to design the territorial division of Spain without consulting with the Basque districtswho held a specific status within Spain, e. Navarre was still a kingdom with its own decision making bodies and customs on the Ebro river. The unilateral decision was regarded as a hostile move, and anger erupted.

The insurrection spread to the Castilla la ViejaAragon and Catalonia where Carlist armies and guerrillas operated until the end of the war. Expeditions outside these areas met with limited success. Carlos the pretender crossed the Bidasoa into French exile, but Carlists in the Catalonia and Aragon continued fighting until Julywhen led by the Ramon Cabrera they escaped to France.

Third Carlist War – Wikipedia

Many prominent figures emerged on both sides during the war. On the liberal side Baldomero Espartero rose to prominence, replacing Maria Cristina as regent inalthough his subsequent unpopularity meant that he was later overthrown by a coalition of politicians and moderate military figures. On the Carlist side Ramon Cabrera rose to become the head of the Carlist party, a position he would hold until – although his switch to the regime in the Third Carlist War would prove crucial.

Fighting concentrated in the mountains of South Catalonia and Teruel until The context was an agricultural and industrial crisis that hit Catalonia intogether with unpopular taxes and military service laws introduced by the mmartinez of Ramon Maria Narvaez. Other critical factor would be the presence of trabucaires or Carlist fighters of the First Carlist War who had not surrendered to the government or fled to exile. Those circumstances resulted in the creation of the first parties in Usually, no more than men and always directed by a cabecilla or chief, often a veteran from the first war, these groups attacked politics and military units.

As ended with an escalation of the fighting, Carlists gathered 4, men in Catalonia backed up by progressives and republicans. In January, liberal army in Catalonia numbered 50, men against 26, Carlists. The detention of Carlos VI in the frontier when he was trying to reach Spain put an end to the uprising in April Outnumbered, without a leader and having failed to achieve a victory in all fronts, Ramon Cabrera and Carlists in Catalonia fled to France in the months of April and May Later, an amnesty announced by the government convinced some of them to return home but most of them stayed in exile.

Beside opposing ideals, ,timo growing Industrial revolution and the constant conflict in the political statements of the society, the Third Carlist War was a culmination of a long political process.

The political image of the conflict, exemplified by the struggle for the Spanish crown emmasked a more crude reality. The expansion of liberal ideals after the Napoleon Bonaparte’s occupation of Spain and the subsequent fight for independence, alarmed Spain’s most traditional sectors who decided to stand and fight for their ideals.

Political reforms carried out by moderate liberals as De la Rosa or Cea BermudezBaldomero Espartero and the government formed after ” La Gloriosa ” in the period extending from toleft the Carlists and other traditional circles in a delicate position. The expropriations of ecclesiastic property carried out by Mendizabalfollowed by those of Espartero and Pascual Madoz were considered as an attack to Church and nobility.

Many nobles and Church lost real estate, which in turn got sold to high-ranking liberals, especially businessmen and merchants.

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These decisions contributed to stir unrest among those two important sectors of Spanish society, but were not the only important sectors to be threatened by the advance of new bourgeois liberalism —in its different versions, both economic and political. The Spanish centralizing drive a rising Spanish nationalism collided with long-running sources of authority other than the Spanish centralist constitution based in Madrid. The litigation over home rule in the Basque Country Basque Provinces and Navarre was an important point of confrontation.

Catalonia and Aragon had lost their specific institutions and laws during and after the War of the Spanish Succession — Nueva Planta decrees—and wanted to win them back.

Carlists upheld these institutions in a way that during the two major Carlist wars and Catalonia and the Basque Country became the epicentres of the fighting. Finally, bkrbon constant political unrest of the reign of Isabel II marhinez many government changes and the discontent of the army officers sent to fight an unsuccessful war in Africaconvinced many traditionalists to employ the choice of an armed uprising to recall their lost privileges back.

The following search of a king ended with the crowning of Amadeo I supported by the moderate liberals, ptimo this decision was not welcomed by the Carlist sector who elevated their leader Carlos VII to the position of claimant to replace the foreign king. Once again, Spain was ready to see another fight for the crown between two declared enemies, but hiding actually a more complex array of political goals and factions.

The Spanish government struggled to balance its finances. The Treasury’s leeway imgles was virtually non-existent, it was unable to buy gold or silver to earn solvency as it would rely on further loan requests to international financiers, [2] either the House of Rothschild or Paribas. However, the loan only extended the political agony and briefly patched the financial gaps, so soon the Treasury was up for another loan request to cover the staggering public debt.

The way found by the successive Spanish governments to fix the financial woes during La Gloriosa was to pay back the debt by making new, vicious loan requests, accepting ever rising interest rates. The House of Rothschild, a major beneficiary of this instability, lost any hope of a recuperation of the Spanish finances, and refused to provide further advances, refraining from engaging in major operations.

The government turned to Paribas for new loans, with the French institution agreeing to a million francs loan, signed in September They found the situation of public finances so ruinous that they avoided embarking in any financial operations. The Spanish government took emergency measures aimed at collecting the funds necessary for their campaign against the Carlist outbreak in the north, some of them breaking the boundaries of what could be acceptable, ethical and economically viable.

Inafter Serrano’s military victory in Bilbao, Alphonse Rothschild wrote to their cousins in London:. The fall of the Carlists will be a great victory for the government That does not seem very probable though, and soon there will be no wealth in Spain.

It is not really in our interest to associate with this looting more or less legal. During the war borboj sides employed different kind of tactics, focused on gaining the upper hand for a final clash that would end the war. The tactics employed showed the different concept of war of both contenders and the nature of the warfare itself, focusing on mountainous and rough terrain ideal for the irregular and guerrilla style warfare.

Third Carlist War

As they had done in the previous Carlist Warsthe Carlists focused on raising war parties commanded by various type of provisional commanders. These war parties would carry on an irregular warfare, focusing on guerrilla or partisan activities, attacking telegram posts, railways, outposts and employing hit and run tactics. The Carlists always tried to avoid great cities such as Bilbao or San Sebastianbecause they were not able to display enough power to commit to the siege and capture of this cities.

Instead, they showed great skill in attacking undefended towns or isolated outposts and employing their knowledge of the terrain to their benefit.

There were also several Carlist armies operating in the main theaters of the war, under the command of Carlos VII ‘s most trusted officers. This armies were composed by royalist volunteers which united under the Carlist bannerforming regular infantry, cavalry and artillery units. Although it was impressive, its real strength was questionable because of the low quality of many of the volunteers, possessing almost no military training and even less discipline.

Another big disadvantage of the Carlist forces was the lack of a defined supply line which translated into a constant lack of horses, ammunition, weapons in case they were much of these were obsolete, artillery pieces These handicaps conditionated the Carlist strategy showing their martinezz to carry on an ordinary warfare, and their willingness to fight a guerrilla warfare and not committing their low trained forces in a inglrs clash with the liberals.

In response to the Carlist dispositions, the Liberals’ plans were to conduct a pacification war and to drive the Carlists into a decisive and direct confrontation where their superior training, equipment and leadership would prove in their words decisive.

These advantages were the control of the railway system, what enabled the transport of troops and inglex from one critical sector to another in a matter of few days, the back up of the regular Spanish magtinez and their experienced troops and officers, the support of the cities and big settlements such as Bilbao and their superiority in equipment, having better and more weapons and more manpower martinea the Carlists.

These, were only shadowed by the political instability of the government that conditioned the campaigns and the resources available to suppress the Carlist uprising. The guerrilla warfare carried on by the Carlists proved to be a challenging task for the liberals because carloe the rough terrain where it was carried on and the ability of the Carlists to employ the surrounding terrain to their benefit. All the advantages that the carlso could have over the Carlists were, however, irrelevant in this kind of terrain, leveling the balance of the war but also restricting it to concrete places of the Spanish geography.

As the French were able to see in the War of Independence the suppression of guerrillas was a very hazardous and costly task that required enormous amounts of manpower and resources that in the first stages of the war the liberals lrimo unable to provide.


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In the dialogue, Socrates discusses with various Athenians and foreigners about the meaning of justice and whether the just man is happier than the unjust man. They also discuss the theory of formsthe immortality of the souland the role of the philosopher and plafo poetry in society. While visiting the Piraeus with GlauconPolemarchus asks Socrates to join him for a celebration.

Socrates then asks Cephalus gadamwr, Polemarchus, and Thrasymachus their definitions of justice. Cephalus defines justice as giving what is owed. Polemarchus says justice is “the art which gives good to friends and evil to enemies. The first book ends in aporia concerning its essence. Socrates believes he has answered Thrasymachus and is done with the discussion of justice. Socrates’ young companions, Glaucon did Adeimantuscontinue the argument of Thrasymachus for the sake of furthering the discussion.

Glaucon gives a speech in which he argues first that the origin of justice was in social contracts aimed at preventing one from suffering injustice and being unable to take revenge, second that plxto those who practice justice do so unwillingly and out of fear of punishment, and third that the life of the unjust man is far more blessed than that of the just man. Glaucon would like Socrates to prove that justice is not only desirable, but that it belongs to the highest class of desirable things: After Glaucon’s speech, Adeimantus adds that, in this thought experiment, the unjust should not unr any sort of divine judgement in the afterlife, since the very poets who wrote about such judgement also wrote that the gods would grant forgiveness to those humans who made ample religious sacrifice.

Adeimantus demonstrates his reason by drawing two detailed portraits, that the unjust man could grow wealthy by injustice, devoting a percentage of this gain to religious sacrifices, thus nud him innocent in the eyes of the gods.

Socrates suggests that they look for justice in a city rather than in an individual man. After attributing the origin of society to the individual not being self-sufficient and xie many needs which he cannot supply himself, they go on to describe the development of the city. Socrates first describes the “healthy state”, but Glaucon asks him to describe “a city of pigs”, as he finds little difference between the two. He then goes on difhter describe the luxurious city, which he calls “a fevered state”.

This begins a discussion concerning the type of education that ought to be given to these guardians in their early dichyer, including the topic of what kind of stories are appropriate. They conclude that stories that ascribe evil to gadamef gods are untrue and should not be taught. Socrates and his companions Adeimantus and Glaucon conclude their discussion concerning education.

Socrates breaks the educational system into two. They suggest that guardians should be educated in these four virtues: They also suggest that the second part of the guardians’ ppato should be in gymnastics.

With physical training they will be able to live without needing frequent medical attention: Socrates asserts that both male and female guardians be given the same education, that all wives and children be shared, and that they be prohibited from owning private property. Socrates and his companions conclude their discussion concerning the lifestyle of the guardians, thus concluding their initial assessment of the city as a whole.

Republic (Plato) – Wikipedia

Socrates assumes each person will be happy engaging in the occupation that suits them best. If the city as a whole is happy, then individuals are happy. In the physical education and diet of the guardians, the emphasis is on moderation, since both poverty and excessive wealth will corrupt them a1. Without controlling their palto, the city cannot control the future rulers.

Socrates says that it is pointless to worry over specific laws, like those pertaining to contracts, since proper education ensures lawful behavior, and poor education causes lawlessness ac.

Socrates proceeds to search for wisdom, courage, and temperance in the city, on the grounds that justice will be easier to discern in what remains e. They find wisdom among the guardian rulers, courage among the guardian warriors or auxiliariestemperance among all classes of the city in agreeing about who should rule and who should be ruled.

Finally, Socrates defines justice in the city as the state in which each class performs only its own work, not meddling in the work of the other classes b. The virtues discovered in the city are then sought in the individual soul. For this purpose, Socrates creates an analogy between the parts of the city and the soul the city-soul analogy. He argues that psychological conflict points to a divided soul, since a completely unified soul could not behave in opposite ways towards the same object, at the same time, and in the same respect b.

Having established the tripartite soul, Socrates defines the virtues of the individual. Socrates, having to his satisfaction defined the just constitution of both city and psyche, moves to elaborate upon the four unjust constitutions of these. Adeimantus and Polemarchus interrupt, asking Socrates instead first to explain how the sharing of wives and children in the guardian class is to be defined and legislated, a theme first touched on in Book III.

Socrates is overwhelmed at their request, categorizing it as three “waves” of attack against which his reasoning must stand firm. These three waves challenge Socrates’ claims that.

Socrates’ argument is that in the ideal city, a true philosopher with understanding of forms will facilitate the harmonious co-operation of all the citizens of the city.

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This philosopher-king must be intelligent, reliable, and willing to lead a simple life. However, these qualities are rarely manifested on their own, and so they must be encouraged through education and the study of The Good. Just as visible objects must be illuminated in order to be seen, so must also be true of objects of knowledge if light is cast on them. Just as light comes dichtfr the Sun, so does truth come from goodness.

Goodness as the source of truth makes it possible for the mind to know, just as light from the Sun makes the eyes able to see. He continues in the rest of this book by further elaborating upon plzto curriculum which a would-be philosopher-king must study.

This is the origin of the quadrivium: Next, they elaborate on the education of the philosopher king. Until age 18, would-be guardians should be engaged in basic intellectual study and physical training, followed by two years of military training.

However, a correction is then introduced where the study of gymnastics martial arts and dichhter – 3 plus 2 years, respectively – are supplanted by philosophy for 5 years instead. Next, they receive ten years of mathematics until age 30, and then five years of dialectic training. Guardians then spend the next 15 years as leaders, trying to “lead people from the cave”. This refers to “the Allegory of the Cave ” Upon reaching 50, they are fully aware of the form of good, and totally mature and ready to lead.

Socrates discusses four unjust constitutions: He argues that a society will decay and pass through each government in succession, eventually becoming a tyranny, the most unjust regime of all.

The starting point is an imagined, alternate aristocracy ruled by a philosopher-king ; a just government dominated by the wisdom-loving element. When its social structure breaks down and enters civil war, it is replaced by timocracy. The timocratic government is dominated by the spirited element, with a ruling class of property-owners consisting of warriors or generals Ancient Sparta is an example.

As the emphasis on honor is compromised by wealth accumulation, it is replaced by oligarchy. The oligarchic government is dominated by the desiring element, in which the rich are the ruling class.

The gap between rich and poor widens, culminating in a revolt by the underclass majority, establishing a democracy. Democracy emphasizes maximum freedom, so power is distributed evenly.

It is also dominated by the desiring element, but in an undisciplined, unrestrained way. The populism of the democratic government leads to mob rule, fueled by fear of oligarchy, which a clever demagogue can exploit to take power and establish tyranny. In a tyrannical government, the city is enslaved to the tyrant, who uses his guards to remove the best social elements and individuals from the city to retain power since they pose a threatwhile leaving the worst.

He will also provoke warfare to consolidate his position as leader. In this way, tyranny is the most unjust regime of all. In parallel to this, Socrates considers the individual or soul that corresponds to each of these regimes.

He describes how an aristocrat may become weak or detached from political and material affluence, and how his son will respond to this by becoming overly ambitious. The timocrat in turn may be defeated by the courts or vested interests; his son responds by accumulating wealth in order to gain power in society and defend himself against the same predicament, thereby becoming an oligarch. The oligarch’s son will grow up with wealth without having to practice thrift or stinginess, and will be tempted and overwhelmed by his desires, so that he becomes democratic, valuing freedom above all.

Having discussed the tyrannical constitution of a city, Socrates wishes to discuss the tyrannical constitution of a psyche. This is all intended to answer Thrasymachus’ first argument in Book I, that the life of the unjust man here understood as a true tyrant is more blessed than that of the just man the philosopher-king. First, he describes how a tyrannical man develops from a democratic household.

The democratic man is torn between tyrannical passions and oligarchic discipline, and ends up in the middle ground: The tyrant will be tempted in the same way as the democrat, but without an upbringing in discipline or moderation to restrain him. Therefore, his most base desires and wildest passions overwhelm him, and he becomes driven by lust, using force and fraud to take whatever he wants. The tyrant is both a slave to his lusts, and a master to whomever he can enslave.

Because of this, tyranny is the regime with the least freedom and happiness, and the tyrant is most unhappy of all, since the regime and soul correspond. His desires are never fulfilled, and he always must live in fear of his victims. Because the tyrant can only think in terms of servant and master, he has no equals whom he can befriend, and with no friends the tyrant is robbed of freedom. This is the first proof that it is better to be just than unjust. The second proof is derived from the tripartite theory of soul.

The wisdom-loving soul is best equipped to judge what is best through reason, and the wise individual judges wisdom to be best, then honor, then desire. This is the just proportion for the city or soul and stands opposite to tyranny, which is entirely satiated on base desires. The third proof follows from this. He describes how the soul can be misled into experiencing false pleasure: True pleasure is had by being fulfilled by things that fit one’s nature.

Wisdom is the most fulfilling and is the best guide, so the only way for the three drives of the soul to function properly and experience the truest pleasure is by allowing wisdom to lead. To conclude the third proof, the wisdom element is best at providing pleasure, while tyranny is worst because it is furthest removed from wisdom. He then gives the example of a chimera to further illustrate justice and the tripartite soul. The discussion concludes by refuting Thrasymachus’ argument and designating the most blessed life as that of the just man and the most miserable life as that of the unjust man.

Concluding a theme brought up most explicitly in the Analogies of the Sun and Divided Line in Book VI, Socrates finally rejects any form of imitative art and concludes that such artists have no place in the just city. He continues on to argue for the immortality of the psyche and even espouses a theory of reincarnation.

He finishes by detailing the rewards of being just, both in this life and the next. Artists create things but they are only different copies of the idea of the original.


Anagarika Shri Munindra ( – ), also called Munindraji by his disciples, was a Bengali vipassana meditation teacher, who taught many. Anagarika Sri Munindra () was the much-beloved Bengali master whose many students included such luminaries as Dipa Ma. Living This Life Fully: Stories and Teachings of Munindra is both an insightful Anāgārika Munindra was a Bengali Buddhist master and scholar who became.

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Anagarika Shri Munindra — anaagrika, also called Munindraji by his disciples, was a Bengali vipassana meditation teacher, who taught many notable teachers including Dipa MaJoseph GoldsteinSharon Salzbergand Surya Das.

Anagarika simply means a practicing Buddhist who leads a homeless life without attachment in order to focus on the Dhamma. Munindra was born in Chittagong, Bangladeshto the Barua family, descendants of the original Buddhists of India forced east by the eleventh-century Muslim invasion.

He was an active member of the Maha Bodhi Society whose purpose was the resuscitation of Buddhism in India and the restoration of ancient Buddhist shrines there. Munindra anagarkka the superintendent of the Maha Bodhi Temple at Bodh Gaya from tothe first Buddhist to hold this position in modern times. From to he lived in Burma where he was a close disciple anzgarika Mahasi Sayadaw, who authorized him to teach vipassana meditation.

Anagarika Munindra | Revolvy

While in Burma he also studied the Pali canon thoroughly, before returning to India where anaggarika taught vipassana for many years in Bodh Gaya. Admired for his gentleness, wisdom, and insatiable curiosity, he had a deep knowledge of the Pali canon which he made accessible to Westerners.

He was also known to be very open-minded and relaxed in the way he taught. He would encourage his students to study munndra other teachers, and investigate other traditions.

The book, Living This Life Fully: Stories and Teachings of Munindra provides a great deal more information about Munindra, by Mirka Knaster wnagarika, For more information on this book, see: Retrieved from ” https: Navigation menu Personal tools Log in. Views Read View source View history.

Navigation Main page Recent changes Random page Help. This page was last edited on 24 Novemberat This page has been accessed 13, times. Privacy policy About Dhamma Wiki Disclaimers.


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Donaghay M, Lessey BA. A critical reanalysis of the accuracy, reproducibility, and clinical utility of histologic endometrial dating: Endocrine regulation of menstruation.

Distribution of estrogen receptors in various cell types of normal, hyperplastic, and neoplastic human endometrial tissues. Endometrial receptivity and human embryo implantation.

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Am J Obstet Gynecol. Interobserver and intraobserver variability in the histological dating of the endometrium in fertile and infertile women. The cell biological basis of human implantation. The role of growth factors and cytokines during implantation: Intfgrinas regulators of implantation.

A morphological analysis of the early implantation stages in the rat. Tabibzadeh S, Babaknia A. The signals and molecular pathways involved in implantation, a symbiotic interaction between blastocyst and endometrium involving adhesion and tissue invasion. The endometrium as a cause of implantation failure. Hormonal control of ovoimplantation. Endometrial gene expression in the itnegrinas of implantation is altered in obese women especially in association with polycystic ovary syndrome.

The impact of luteal phase support kntegrinas gene expression of extracellular matrix protein and adhesion molecules in the human endometrium during the window of implantation following controlled ovarian stimulation with a GnRH antagonist protocol. Wang J, Armant DR. Integrin-mediated adhesion and signalling during blastocyst implantation.

Singh H, Aplin JD. Adhesion molecules in endometrial epithelium: A targeted mutation in the mouse E-cadherin gene results in defective preimplantation development.

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Alteration of E-cadherin, alpha- and beta-catenin mRNA expression in human uterine endometrium during the menstrual cycle. Expression of cadherins and CD44 isoforms in human endometrium and peritoneal endometriosis.

Acta Obstet Gynecol Scand. Calcitonin down-regulates E-cadherin expression in rodent uterine epithelium during implantation. Progesterone induces calcitonin gene expression in human endometrium within the putative window of implantation. Smalley DM, Ley K. J Cell Mol Med.

Alon R, Feigelson S. From rolling to arrest on blood vessels: Trophoblast L-selectinmediate dadhesion at the maternal-fetal interface.

Differential expression of L-selectin ligand in the endometrium during the menstrual cycle. What makes an embryo stick? Uterine leukocytes and decidualization.

The role of leukocyte traffic and activation in parturition. J Soc Gynecol Invest. Unexplained habitual abortion is integrinass with a reduced endometrial release of soluble intercellular adhesion molecule-1 in the luteal phase of the cycle. Nikas G, Aghajanova L. Assisted reproductive technology in Europe, Steroid receptor coactivator expression throughout the menstrual cycle in normal and abnormal endometrium.

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Endometrial expression of Cyr Todos os direitos reservados. All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License.

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One primary SSID and at most seven guest SSIDs depending on model can be configured to allow virtual segregation stations which share the same channel.

Warranty & Support

Add as many as you want or the amount supported by the AP from the Index list. Once again, click on the ADD button to make the changes. Click on ADD for each addition. Click on Apply to finalize. A Dynamic Pool allows wireless stations to receive an available IP with lease time control.

This protocol simplifies network management and allows new wireless devices to receive IP addresses automatically without the need to manually assign new IP addresses. Enter the number of IP addresses available for assignment. All devices in the network must have the same subnet mask to communicate. Enter the d-linj for the network here.

The DNS server translates domain names such as www. Enter the domain name of the network, if applicable.

An example of a domain name is: Dap dapp-2553, Dynamic Pool. Quality of Service QoS enhances the experience of using a network by prioritizing the traffic of different applications. A QoS Rule identifies a specific message flow and assigns a priority to that flow. For most applications, the priority classifiers ensure the right priorities and specific QoS Rules are not required. QoS supports overlaps between rules.

If more than one rule matches a specific message flow, the rule with the highest priority will be used. Such streams are frequently used by digital media players. When enabled, this option causes the access point to automatically attempt to prioritize traffic streams that it does not otherwise recognize, based on the behavior that the streams exhibit.

This acts to de-prioritize streams that exhibit bulk transfer characteristics, such as file transfers, while leaving interactive traffic, such as gaming or VoIP, dap-2535 at a normal priority.

Use the drop-down menu to select the desired priority: Use vap-2553 drop-down menu to choose the appropriate protocol used da-2553 the messages: Host 1 IP Range: Host 1 Port Range: Host 2 IP Range: Host 2 Port Range: Access PointDapQoS. All other devices not on the list will be rejected.

All other devices not on the list will be accepted. Enter cap-2553 MAC address that you wish to include in your filter list, and click Save.

D-Link Technical Support

When you enter a MAC address, it appears in this list. Highlight a MAC address and click Delete to remove it from this list. You dap-253 create an ACL list and upload it to the access point instead of manually entering the information. Once created, click the Browse button and locate your file. Select it and then click Upload. The default is Enable. When disabled, all data from the Ethernet to associated wireless devices will be blocked. Wireless devices can still send data to the Ethernet.

The default value is Enable, which allows stations to inter-communicate by connecting to a target AP. When disabled, wireless stations cannot exchange data through the AP. The log information includes but is not limited to the following items: The web page holds up to logs.

Dap | Dlink products Configuration And Installation On D-Link Blog Home

Log Settings on DAP Check the box for the type of activity you d-lin, to log. There are three types: System Activity, Wireless Activity, and Notice.

Check to enable Email notification. Select the SMTP server from the drop-down menu. Select when to send the log to your email in hours. You will receive an email when the log is full too. DaplogLog Settings.

How to fix slow webpage load speeds on DIRL when used with some mobile devices? The status light dap-25553 the D-Link router is flashing what is it indicating? How to hard reset D-Link Wireless router to default settings? The status light on D-Link router is flashing what is it indicating? Get complete infor ….

As most APs, the default static IP address is Input the first IP address available for assignment on your network. The Range of Pool Enter the IP address of the gateway on the network. Lease Dap-253 sec: QoS Quality of Service: Enable this option if you want to allow QoS to prioritize your traffic Priority Classifiers. Enter a name for the dqp-2553 QoS rule in the field provided. Displays the current wireless band rate. Select Disable to disable the filters function.

Click Download to export the ACL to a file on your computer. Select Enable or Disable.

D-Link DAP-2553 Wireless-N Dual Band Gigabit Access Point w/ PoE

Check to enable authentication. Enter the destination email address. Enter the Email Server Address. Enter the SMTP port. Enter your email username. Enter your email password.

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No other units of measurement are included in this standard.

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