Carcinoma Mucoepidermoide de Glándulas Salivales Intraoral: Factores Clínicos y Patológicos e Inmunoexpresión de c-erbB-2 en 29 Casos. Vanessa Fátima. Publisher: El propósito de este estudio es presentar la casuística del carcinoma mucoepidermoide de glándulas salivales de pacientes diagnosticados en el. English: Tumors of the salivary glands represent % of head and neck neoplasms. Mucoepidermoid carcinoma (MEC) is the most common epithelial.

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Complete resection was defined as a histological report of negative margins of more than 10 mm. A total of 16 cases were analyzed over a period of 18 years; males were Few papers evaluating only one type of oral salivary gland tumors are available.

Carcinoma mucoepidermoide

Surgical resection was performed in all patients. Although MEC has been described as a radioresistant tumor, postoperative radiotherapy has been associated with decreased recurrence in some reports. Growth Factors, 24 2: MECs were staged according to the TNM classification of malignant tumors, 12 and minor salivary gland tumors were staged according to their site of origin in a similar fashion to squamous cell carcinomas.

Discrepancies were solved by consensus.

Additionally, a significant influence on prognosis was observed in DFS curves depending on the primary anatomical site.

Selecting antibodies to detect HER2 overexpression by immunohistochemistry in invasive mammary carcinomas. Coexpression of p53 and c-erbB-2 proteins is associated with histological type, tumour stage, and cell proliferation in malignant salivary gland tumours. However, many studies found that benign and malignant salivary gland neoplasms with evidence of myoepithelial lineage do not overexpress c-erbB-2 protein which support the view that this growth receptor mucoelidermoide not involved in their pathogenesis Rosa carcinpma al.


There were 16 cases of MEC diagnosed over an year period at our institution, which is similar to results reported by Triantafillidou and others 14 who found 16 cases over a year interval.

In contrast to results reported by Nance and others 4 in present study was not observed mkcoepidermoide association between positive surgical margins and decreased DFS. Most of the studies show that the palate is the most common site of ocurrence Lopes et al.

Jpn J Clin Oncol. Mucoepidermoid tumors of the salivary glands. Otolaryngol Head Neck Surg. Sinonasal and maxillary tumors were not included in this study as intraoral salivary gland tumors since that in these locations mucoepidermoid carcinoma presents different origin rather than glandular Ellis et al.

Mucoepidermoid carcinoma MEC is the most common epithelial neoplasm in the salivary glands; the biological behavior relates to a histological grade of the tumor low, intermediate and high grade. Treatment and survival outcomes based on histologic grading in patients with head and neck mucoepidermoid carcinoma. The palate was the most commonly affected site, with 21 cases Immunohistochemical study of c-erbB-2 oncoprotein overexpression in mucoepidermiide major salivary gland carcinoma: Immunoexpression of c-erbB-2 and p53 in benign and malignant salivary neoplasms with myoepithelial differentiation.

The three-level grading system commonly used by pathologists for MEC classification mainly considers the relative proportion of cell types epidermoid, intermediate and mucinous cellstheir respective degrees of atypia and growth patterns cystic, solid, or infiltrativetogether with neural and salivqles invasion. The biological features and clinical behavior of mucoepidermoid carcinomas are widely variable and poorly understood.


There is a growing consensus that an aggressive surgical approach with adjuvant radiotherapy must always be considered for more advanced cases that present with a high histological xarcinoma, positive margins and cervical involvement.

We suppose that reasons for this contradictory results are associated with the immunohistochemistry technique, in special with the primary antibody employed and with the subjective interpretation and semiquantitative nature of the results.

Carcinoma mucoepidermoide

Cytoplasmic expression was also observed but not considered in this study as reported in diverse salivary gland tumors Kernohan et al. Studies on intra-oral MEC have shown similar results with a higher percentage of low grade tumors Kokemueller et al.

Tumors were more common in the third and fourth decades of life Mucoepidermoid carcinoma of the salivary glands clinical review of 42 cases. It is composed of mucous, epidermoid, intermediate, columnar and clear dd. Briefly, 4 um sections were dewaxed in xylene and hydrated with graded ethanol.

Surgical Pathology ofthe salivary glands. The follow-up period in this study ranged from 6 to months. Otolaryngol Head Neck Surg. University of Sao Paulo, Brazil. Mucoepidermoid carcinoma of the cwrcinoma glands: