The Milan criteria are a generally accepted set of criteria used to assess suitability in patients for liver transplantation with cirrhosis and hepatocellular carcinoma. Avaliação do tratamento dos nódulos do hepatocarcinoma nos pacientes em lista entre pacientes incluídos no Critério de Milão ou ao downstaging (p= 0,). .. Yan L. Downstaging advanced hepatocellular carcinoma to the Milan criteria. Catorze diferentes critérios foram encontrados e descritos em detalhes. The keywords used were hepatocellular carcinoma, liver transplantation, expanded.

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In conclusion, the EMC is useful attempt for widening the preexistent protocol for patients with HCC in the waiting-list for OLT, however there is no significant difference in patient survival rate and tumor recurrence free rate from those patients that followed the MC. Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis.

Up-to-seven criteria for hepatocellular carcinoma liver transplantation: A single center analysis

N Engl J Med. Vascular invasion and histhopathologic grading determine outcome after liver transplantation for hepatocellular carcinoma in cirrhosis. Therefore, the Milan group Mazzaferro et al[ 11 ] attempted to expand the Milan criteria and create a new set called the up-to-seven criteria new Milan criteria: Open in a separate window. We did not evaluate the new targets in the out up-to-seven group because there were some cases with diffused tumors, so finding and calculating new tumor targets would have been very difficult in these patients.

Milan criteria – Wikipedia

Determinamos igualmente, cuando fue posible, la causa fundamental del fallecimiento. Por otra parte, en el ya citado trabajo de Pignata y cols. Downstaging advanced hepatocellular carcinoma to the Milan criteria may provide a comparable outcome to conventional Milan criteria.

So considering that patients in the up-to-seven criteria group exhibited a considerable but lower survival rate compared with the Milan criteria group, the up-to-seven criteria should be used carefully and selectively. Waiting time predicts survival after liver transplantation for hepatocellular carcinoma: Survival and tumor recurrence The length of follow-up for all the patients in our study was at least 5 years, and no significant differences were observed among the groups.


Small bowel Bariatric surgery Duodenal switch Jejunoileal bypass Bowel resection Ileostomy Intestine transplantation Jejunostomy Partial ileal bypass surgery Strictureplasty. We compiled data focusing on patient survival rate and tumor recurrence free rate from 1 to 5-years. To detect whether the up-to-seven should be used as inclusion criteria for liver transplantation for hepatocellular carcinoma. Cost effectiveness of adjuvant therapy for hepatocellular carcinoma during the waiting list for liver transplantation.

Patients with cholangio-hepatocellular cancer or other liver diseases were excluded from this study.

Dee Clin Oncol ; Living donor liver transplantation versus deceased donor liver transplantation for hepatocellular carcinoma: The baseline characteristics of transplant recipients were comparable among these three groups, except for the type of liver graft deceased donor liver transplant or live donor liver transplantation.

Donor safety in living donor critefios transplantation: Up-to-seven criteria, Liver transplantation, Outcome, Hepatocellular carcinoma, Recurrence. Between April and Julyhepatocellular carcinoma HCC patients who were diagnosed with HCC and underwent liver transplantation LT at our liver transplantation center were included.

Hepatocellular carcinoma gepatocarcinoma extremely elderly patients: Thanks for the data from the Chinese Liver Transplant Registry http: For grafts that came from living donors, the donor was required to be within three degrees of consanguinity with the recipient, as verified by a DNA test, and all of the living donor liver transplantations were performed after obtaining approval from the Ethics Committee of the West China Hospital and local authorities.

Marsh JW, Dvorchik Ee. The 1- 3- and 5-year overall and tumor-free survival rates of Milan criteria group were superior to those of the up-to-seven patients [ Eleazar Chaib Avenida Dr.

No prisoners were included as donors, and all of the whole liver grafts were donations after cardiac death. Treatment hepatocarcinlma for small hepatocellular carcinoma: Liver transplantation for hepatocellular carcinoma: Servicio de Medicina Interna. Although more patients were diagnosed with recurrence or metastasis in the out up-to-seven group than in the other groups, the site of recurrence or metastasis was not significantly different among the three groups.


Some have advocated for the use of expanded guidelines for liver transplantation in the setting of HCC.

Milan criteria

Surgical resection versus transplantation for early hepatocellular carcinoma: Review compiled data from 23 articles. From Wikipedia, the free encyclopedia. Retrieved from ” https: Orthotopic liver transplantation is an excellent treatment approach for hepatocellular carcinoma in well-selected candidates.

However, the criteria proposed by the University of Pittsburgh and some groups in Europe are based, at least in part, on pathological features nodal invasion, grade, vascular invasion that are not usually available before transplantation 9, 21, 50, The patient survival rate and tumor recurrence-free rates from 1 to 5-years were shown in Table 1.

Liver transplantation and expanded Milan criteria: does it really work?

However there is no significant difference in patient survival rate and tumor recurrence free rate from those patients that followed the Milan criteria. Systematic review of randomized trials for unresectable hepatocellular carcinoma: Takada Y, Uemoto S.

Although the up-to-seven criteria group included 90 patients, which was much higher than the number of patients in the Milan criteria group 53 casesthe main aim of hepahocarcinoma the Milan criteria was to include more HCC patients without compromising outcomes; this, in our study, long-term 5-year survival was much lower in the up-to-seven group. All of these patients were diagnosed with HCC based on pre-operative imaging studies, and the diagnoses were confirmed by pathology.

Liver transplantation and expanded Milan criteria. The most common etiology of cirrhosis was hepatitis B infection.

The data collected were based on the online database PubMED. Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis.