HYVET STUDY PDF

Keywords: elderly, hypertension, HYVET, older adults, treatment In the pilot study, subjects aged over 80 years, with a sustained blood. Kardiol Pol. Jul;66(7); discussion [HYVET study – treatment for hypertension]. [Article in Polish]. Zalewska J(1). Author information. “In the main HYVET study, we aimed to resolve persistent areas of clinical uncertainty about the relative benefits and risks of antihypertensive.

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Formal education was protective HR 0. The investigators also observed a non-significant reduction in the primary outcome measure, stroke, unadjusted hazard ratio HR 0. At 2 years there were no significant changes in serum potassium, uric acid, glucose and creatinine between the trial arms [ 13 ]. All authors have completed the Unified Competing Interest form at http: Views Read View source View history.

The role of blood pressure control in preventing complications of hypertension.

N Engl J Med. This page was last modified on 11 Januaryat Trial participants receiving double-blind treatment at their final visit within the main study were deemed eligible for inclusion.

The Hypertension in the Very Elderly Trial – latest data

Earlier this year, results from a 1 year open label active treatment extension of HYVET were published. Although the model requires further hyve, it suggests that cognitive change in those aged over 80 years is small, depends on baseline cognitive function and the relative efficacy of anti-hypertensive treatment [ 25 ].

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Yet the authors of the meta-analysis noted that a single, randomized controlled trial demonstrating no benefit from anti-hypertensive therapy, in this cohort, would negate the apparent benefits seen across their meta-analysis [ 11 ]. Mortality by race-sex and age. Association of depression with subsequent mortality, cardiovascular morbidity and incident dementia in people aged 80 and over and suffering from hyyvet.

Published online Aug Moreover, active treatment was well tolerated. Author information Article notes Copyright and License information Disclaimer. Navigation menu Personal tools Create account Log in.

This article has studu cited by other articles in PMC. Main study findings A double-blind placebo-controlled trial with recruitment centres in 13 countries, HYVET prospectively analyzed data from older adults.

Treatment of hypertension in the elderly. Stepwise treatment consisted of a diuretic indapamide sustained release 1.

Whilst each additional GDS point at baseline also increased these risks, the study was not designed to evaluate this association. National Center hvyet Biotechnology InformationU. The s saw publication of landmark data demonstrating the benefits of anti-hypertensive therapy [ 1 — 3 ]. Once again, the relative well being of the trial participants limits the potential applicability of these data to the general population.

[HYVET study – treatment for hypertension].

Furthermore, standing and seated BPs post-treatment were equivalent, suggesting that antihypertensive therapy was not associated with orthostatic hypotension [ 13 ]. This review provides an overview of the Hypertension in the Very Elderly Trial whilst also discursively evaluating the latest data. Whilst a statistically significant reduction in congestive cardiac failure was also observed unadjusted Studt 0.

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In addition, it was notable that four centres closed in the first year due to data quality issues [ 13 ]. Medical Research Council trial of treatment of hypertension in older adults: Five-year findings jyvet the Hypertension Detection and Follow-up Program: The trial steering group also published an analysis evaluating the association of depression with cardiovascular mortality and morbidity, all-cause mortality and incident dementia.

HYVET also has a number of methodological issues, namely the protocol amendment which provided for the inclusion of subjects with ISH and the variable methods for measuring blood pressure.

The Hypertension in the Very Elderly Trial – latest data

A double-blind placebo-controlled trial with recruitment centres in 13 countries, HYVET prospectively analyzed data from older adults. The optimal target BP among very elderly patients has yet to be defined. Whilst these results strengthen the case for early benefit arising from anti-hypertensive therapy in octogenarians, the selective exclusion criteria are questionable.

The New England Journal of Medicine. However, with the passage of time, a progressive effort has been made to expand the evidence base for treatment in older adults.